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Maybe there are other mechanisms by which fasting works, but, as you know, it promotes autophagy. And, on your recommendation, I am taking resveratrol 500mg twice daily and spermidine, both of which promote autophagy.

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Clonodine is another well known alpha agonist that presumably would have a similar effect.

I think Taurine has positive effects on GABA.

I am also curious about niacinamide, the virtues of which have long been extolled by Ray Peat forum members.

https://raypeatforum.com/community/threads/the-anti-cortisol-effects-of-niacinamide.9887/

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Thanks for the raypeatforum link, I didn't realize there was a link between niacinamide & lowering cortisol levels.

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Yes clonidine is more frequently used in the US than Guanfacine for hypertension. I had never actually seen Guanfacine prescribed to anyone as an adult hospitalist.

I need to look into niacin, niacinamide, NAD, & NMN in more detail. Have heard good things about all of them.

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